The permanent collection of the Archaeological Museum of Igoumenitsa, entitled "Thesprotians’ Land", is displayed on the three floors of the building, covering a large time span from the Middle Palaeolithic (c. 100,000 years before present) up to the late Roman times, while it comprises a small number of exhibits of the Byzantine – post Byzantine era.
Through five thematic sections and more than 1600 exhibits, the long history and rich past of Thesprotia is presented, focusing mainly on the Hellenistic period, which is an era of wealth and prosperity and particularly representative of the region.
The exhibits, many of which were previously displayed or stored in the archaeological museums of Corfu and Ioannina, come from archaeological excavations conducted since the 1960s throughout the Regional Unit of Thesprotia which for the most part coincides with the geographical boundaries of ancient Thesprotia.